Two sample MR report

Telomere_length against wg rh intensity-contrast unknown

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0468923	0.1308990	0.7237452
Weighted median	23	0.0086192	0.0595797	0.8849742
Inverse variance weighted	23	0.0216264	0.0503590	0.6675998
Simple mode	23	0.0926160	0.1100496	0.4090761
Weighted mode	23	-0.0040147	0.0624636	0.9493335

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.41405	21	0.0196351
Inverse variance weighted	36.97478	22	0.0238070

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.004207	0.0073981	0.5756166

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011298	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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