Two sample MR report

Telomere_length against wg rh intensity-contrast transversetemporal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0297086	0.1352564	0.8282673
Weighted median	23	-0.0460505	0.0621591	0.4587851
Inverse variance weighted	23	-0.0289586	0.0519126	0.5769582
Simple mode	23	0.0316614	0.1154134	0.7863906
Weighted mode	23	-0.0590670	0.1000468	0.5609431

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.87982	21	0.0101448
Inverse variance weighted	39.29092	22	0.0130667

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036022	0.0076445	0.6423438

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012074	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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