Two sample MR report

Telomere_length against wg rh intensity-contrast temporalpole

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0447468	0.1131537	0.6964983
Weighted median	23	-0.1737789	0.0616497	0.0048201
Inverse variance weighted	23	-0.2055332	0.0455860	0.0000065
Simple mode	23	-0.1204720	0.1018567	0.2495292
Weighted mode	23	-0.1355171	0.0721626	0.0737093

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.21144	21	0.1639636
Inverse variance weighted	30.29930	22	0.1113693

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0098722	0.0063952	0.1375975

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017664	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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