Two sample MR report

Telomere_length against wg rh intensity-contrast supramarginal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0902769	0.1593193	0.5769649
Weighted median	23	-0.2100670	0.0705347	0.0028994
Inverse variance weighted	23	-0.1756862	0.0613163	0.0041669
Simple mode	23	-0.3327931	0.1338502	0.0209847
Weighted mode	23	-0.2438472	0.1267580	0.0674240

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	53.94816	21	0.0001005
Inverse variance weighted	54.81952	22	0.0001260

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0052442	0.0090045	0.5664998

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0022808	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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