Two sample MR report

Telomere_length against wg rh intensity-contrast superiortemporal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1226223	0.1612418	0.4554177
Weighted median	23	-0.1957958	0.0678981	0.0039307
Inverse variance weighted	23	-0.1799107	0.0617791	0.0035894
Simple mode	23	-0.2033044	0.1174508	0.0974594
Weighted mode	23	-0.2268792	0.1118831	0.0548594

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	55.25911	21	6.48e-05
Inverse variance weighted	55.65114	22	9.59e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035176	0.0091132	0.7033894

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0023361	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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