Two sample MR report

Telomere_length against wg rh intensity-contrast superiorparietal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0868442	0.1515393	0.5726764
Weighted median	23	-0.1816671	0.0658600	0.0058088
Inverse variance weighted	23	-0.1536636	0.0581721	0.0082531
Simple mode	23	-0.4171047	0.1207761	0.0022625
Weighted mode	23	-0.2590854	0.1118698	0.0302688

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.80817	21	0.0005331
Inverse variance weighted	49.34150	22	0.0007193

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041028	0.0085648	0.6368691

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019693	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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