Two sample MR report

Telomere_length against wg rh intensity-contrast superiorfrontal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1014521	0.1464007	0.4959181
Weighted median	23	-0.2098435	0.0654318	0.0013410
Inverse variance weighted	23	-0.1919239	0.0564906	0.0006802
Simple mode	23	-0.2622286	0.1198787	0.0396245
Weighted mode	23	-0.2503922	0.1110110	0.0343801

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.55231	21	0.0014649
Inverse variance weighted	46.52998	22	0.0016893

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005555	0.0082743	0.5093129

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0021493	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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