Two sample MR report

Telomere_length against wg rh intensity-contrast rostralmiddlefrontal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0392834	0.1257831	0.7578844
Weighted median	23	-0.1383610	0.0600091	0.0211293
Inverse variance weighted	23	-0.1610754	0.0513329	0.0017019
Simple mode	23	-0.2637098	0.1078530	0.0229508
Weighted mode	23	-0.1727074	0.1013822	0.1025561

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.62496	21	0.0397305
Inverse variance weighted	38.41986	22	0.0164306

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.012302	0.007109	0.098213

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016852	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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