Two sample MR report

Telomere_length against wg rh intensity-contrast rostralanteriorcingulate

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0769133	0.1205222	0.5302632
Weighted median	23	-0.0785579	0.0589592	0.1827251
Inverse variance weighted	23	-0.0882608	0.0460252	0.0551539
Simple mode	23	-0.0394286	0.0964270	0.6865694
Weighted mode	23	-0.0744640	0.0672799	0.2803452

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.86853	21	0.0758740
Inverse variance weighted	30.88390	22	0.0985157

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006967	0.0068117	0.9195006

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010922	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8