Two sample MR report

Telomere_length against wg rh intensity-contrast precentral

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2098353	0.1393050	0.1468851
Weighted median	23	-0.1662769	0.0613805	0.0067496
Inverse variance weighted	23	-0.1311233	0.0536608	0.0145431
Simple mode	23	-0.2839644	0.1072340	0.0146891
Weighted mode	23	-0.2091956	0.1012223	0.0507311

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.24347	21	0.0052308
Inverse variance weighted	41.98350	22	0.0062797

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048329	0.0078732	0.5459118

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016174	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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