Two sample MR report

Telomere_length against wg rh intensity-contrast posteriorcingulate

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0048899	0.1371662	0.9718985
Weighted median	23	-0.0802355	0.0650568	0.2174585
Inverse variance weighted	23	-0.0965295	0.0530214	0.0686713
Simple mode	23	-0.1943543	0.1238320	0.1308037
Weighted mode	23	-0.1236913	0.1008899	0.2331596

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.98599	21	0.0074660
Inverse variance weighted	40.98905	22	0.0082658

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0056267	0.0077524	0.4759715

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001429	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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