Two sample MR report

Telomere_length against wg rh intensity-contrast postcentral

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0454072	0.1567229	0.7748646
Weighted median	23	-0.1312664	0.0663850	0.0480019
Inverse variance weighted	23	-0.0764720	0.0599023	0.2017388
Simple mode	23	-0.2198463	0.1224824	0.0864190
Weighted mode	23	-0.1727026	0.1308690	0.2005174

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	52.20338	21	0.0001787
Inverse variance weighted	52.31865	22	0.0002825

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019074	0.0088577	0.8315818

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017027	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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