Two sample MR report

Telomere_length against wg rh intensity-contrast pericalcarine

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1021776	0.1284650	0.4352949
Weighted median	23	-0.0503368	0.0608043	0.4077558
Inverse variance weighted	23	-0.0735183	0.0515604	0.1539068
Simple mode	23	-0.0624301	0.1218159	0.6134118
Weighted mode	23	-0.0256639	0.0860228	0.7682445

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.07338	21	0.0277160
Inverse variance weighted	38.76042	22	0.0150303

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0107878	0.0072606	0.1521915

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001283	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8