Two sample MR report

Telomere_length against wg rh intensity-contrast parstriangularis

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0188114	0.1461735	0.8988257
Weighted median	23	-0.1578585	0.0660596	0.0168649
Inverse variance weighted	23	-0.1360082	0.0568071	0.0166562
Simple mode	23	-0.2424900	0.1161729	0.0486557
Weighted mode	23	-0.1655578	0.0918415	0.0851611

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.41084	21	0.0015293
Inverse variance weighted	47.05144	22	0.0014451

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0071958	0.0082613	0.3935897

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001797	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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