Two sample MR report

Telomere_length against wg rh intensity-contrast parsorbitalis

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0754332	0.1349701	0.5821497
Weighted median	23	-0.1709077	0.0637483	0.0073408
Inverse variance weighted	23	-0.1633940	0.0521415	0.0017264
Simple mode	23	-0.0293917	0.1134771	0.7980357
Weighted mode	23	-0.1604295	0.0860443	0.0756492

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.71333	21	0.0106182
Inverse variance weighted	39.63741	22	0.0119153

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0054008	0.0076283	0.486729

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017369	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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