Two sample MR report

Telomere_length against wg rh intensity-contrast parsopercularis

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0094831	0.1370911	0.9455055
Weighted median	23	-0.1273574	0.0620175	0.0400170
Inverse variance weighted	23	-0.1798075	0.0545633	0.0009828
Simple mode	23	-0.2042480	0.1123977	0.0828360
Weighted mode	23	-0.1520193	0.0978150	0.1344171

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.94310	21	0.0075561
Inverse variance weighted	43.40827	22	0.0042019

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0104579	0.007748	0.1914703

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019643	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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