Two sample MR report

Telomere_length against wg rh intensity-contrast parahippocampal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2265707	0.1272014	0.0893511
Weighted median	23	-0.1929159	0.0637233	0.0024667
Inverse variance weighted	23	-0.1735468	0.0488007	0.0003762
Simple mode	23	-0.2213922	0.1102157	0.0569963
Weighted mode	23	-0.2173098	0.1018903	0.0443475

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.38727	21	0.0329249
Inverse variance weighted	34.72309	22	0.0414038

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032557	0.0071892	0.6552949

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001657	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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