Two sample MR report

Telomere_length against wg rh intensity-contrast paracentral

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2497531	0.1255299	0.0598169
Weighted median	23	-0.0841735	0.0586958	0.1515544
Inverse variance weighted	23	-0.0938839	0.0499596	0.0602180
Simple mode	23	-0.0907253	0.0948329	0.3491214
Weighted mode	23	-0.0954593	0.0600995	0.1264755

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.48900	21	0.0410684
Inverse variance weighted	36.39085	22	0.0275619

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0095704	0.0070947	0.1917198

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012797	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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