Two sample MR report

Telomere_length against wg rh intensity-contrast middletemporal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0375669	0.1398547	0.7908480
Weighted median	23	-0.1589139	0.0667133	0.0172169
Inverse variance weighted	23	-0.1647850	0.0546226	0.0025547
Simple mode	23	-0.2368136	0.1315371	0.0855326
Weighted mode	23	-0.1939844	0.1186800	0.1163802

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.56953	21	0.0047640
Inverse variance weighted	43.50268	22	0.0040902

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0078112	0.0079043	0.3342942

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018634	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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