Two sample MR report

Telomere_length against wg rh intensity-contrast medialorbitofrontal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0083186	0.0994061	0.9341013
Weighted median	23	-0.0721689	0.0577703	0.2115781
Inverse variance weighted	23	-0.1316456	0.0388452	0.0007015
Simple mode	23	-0.2825333	0.1100542	0.0175737
Weighted mode	23	-0.0445491	0.0669617	0.5127785

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.26707	21	0.6947954
Inverse variance weighted	19.60683	22	0.6076185

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0085937	0.0056182	0.1410334

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009421	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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