Two sample MR report

Telomere_length against wg rh intensity-contrast lingual

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0483923	0.1507366	0.7513539
Weighted median	23	-0.0491388	0.0630864	0.4360305
Inverse variance weighted	23	-0.1099410	0.0593077	0.0637766
Simple mode	23	-0.0621050	0.1433005	0.6689512
Weighted mode	23	-0.0469453	0.0991829	0.6406473

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.29031	21	0.0006277
Inverse variance weighted	51.28474	22	0.0003921

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0097217	0.0085193	0.2666605

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017967	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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