Two sample MR report

Telomere_length against wg rh intensity-contrast lateralorbitofrontal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0739622	0.1476783	0.6216976
Weighted median	23	-0.1902059	0.0685152	0.0055013
Inverse variance weighted	23	-0.1689265	0.0570337	0.0030578
Simple mode	23	-0.2663128	0.1215090	0.0392760
Weighted mode	23	-0.2102023	0.1075268	0.0634204

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.35145	21	0.0011472
Inverse variance weighted	47.42866	22	0.0012900

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0058308	0.0083465	0.4924688

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00201	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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