Two sample MR report

Telomere_length against wg rh intensity-contrast lateraloccipital

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0205478	0.1253864	0.8713956
Weighted median	23	-0.1938811	0.0633799	0.0022205
Inverse variance weighted	23	-0.1459632	0.0501883	0.0036339
Simple mode	23	-0.2342049	0.0993535	0.0277204
Weighted mode	23	-0.2099994	0.0834843	0.0196912

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.41482	21	0.0418150
Inverse variance weighted	36.72669	22	0.0253416

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0102239	0.0070867	0.1638553

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015407	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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