Two sample MR report

Telomere_length against wg rh intensity-contrast isthmuscingulate

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0503186	0.1465538	0.7347523
Weighted median	23	-0.1308692	0.0650702	0.0443045
Inverse variance weighted	23	-0.1014263	0.0576148	0.0783362
Simple mode	23	-0.2729413	0.1259465	0.0413248
Weighted mode	23	-0.1480101	0.0872300	0.1038433

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.64992	21	0.0014220
Inverse variance weighted	48.40049	22	0.0009604

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0093173	0.008283	0.2733389

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016731	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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