Two sample MR report

Telomere_length against wg rh intensity-contrast insula

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0000737	0.1561544	0.9996279
Weighted median	23	-0.0559730	0.0609217	0.3582166
Inverse variance weighted	23	-0.1155667	0.0605303	0.0562313
Simple mode	23	0.0689087	0.1122502	0.5455875
Weighted mode	23	-0.0287248	0.0797429	0.7221192

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	51.82333	21	0.0002023
Inverse variance weighted	53.42061	22	0.0001984

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0071002	0.0088254	0.4301095

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018864	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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