Two sample MR report

Telomere_length against wg rh intensity-contrast inferiortemporal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0873440	0.1256074	0.4944453
Weighted median	23	-0.1295765	0.0633086	0.0406832
Inverse variance weighted	23	-0.1674545	0.0485007	0.0005552
Simple mode	23	-0.0936790	0.1184266	0.4373715
Weighted mode	23	-0.0897987	0.0936320	0.3479506

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.53053	21	0.0406555
Inverse variance weighted	34.29707	22	0.0458108

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0049188	0.0070991	0.4959777

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016023	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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