Two sample MR report

Telomere_length against wg rh intensity-contrast inferiorparietal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0015914	0.1325349	0.9905333
Weighted median	23	-0.2261121	0.0621099	0.0002721
Inverse variance weighted	23	-0.1885853	0.0533565	0.0004086
Simple mode	23	-0.3332706	0.1115658	0.0067929
Weighted mode	23	-0.2853993	0.0971721	0.0076271

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.33359	21	0.0154085
Inverse variance weighted	41.51038	22	0.0071611

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0114815	0.0074906	0.1402571

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001972	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8