Two sample MR report

Telomere_length against wg rh intensity-contrast fusiform

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0756498	0.1442221	0.6053988
Weighted median	23	-0.1845576	0.0654307	0.0047925
Inverse variance weighted	23	-0.1714485	0.0557415	0.0020995
Simple mode	23	-0.2721162	0.1215414	0.0356028
Weighted mode	23	-0.2031315	0.0995234	0.0534231

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.20678	21	0.0021982
Inverse variance weighted	45.30298	22	0.0024286

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005882	0.0081511	0.4784843

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019629	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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