Two sample MR report

Telomere_length against wg rh intensity-contrast frontalpole

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1590922	0.0994065	0.1244426
Weighted median	23	-0.1282942	0.0558952	0.0217181
Inverse variance weighted	23	-0.1311434	0.0388455	0.0007354
Simple mode	23	-0.1424325	0.0846565	0.1066172
Weighted mode	23	-0.1374373	0.0596461	0.0310310

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.43266	21	0.8503074
Inverse variance weighted	14.52596	22	0.8817664

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017161	0.0056183	0.7630351

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007855	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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