Two sample MR report

Telomere_length against wg rh intensity-contrast entorhinal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2932946	0.1350430	0.0414668
Weighted median	23	-0.1623585	0.0621131	0.0089511
Inverse variance weighted	23	-0.1569311	0.0530147	0.0030750
Simple mode	23	-0.2243595	0.1306458	0.0999690
Weighted mode	23	-0.1803250	0.0724255	0.0208256

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.75845	21	0.0104879
Inverse variance weighted	40.97953	22	0.0082874

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0083728	0.0076324	0.2850596

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017362	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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