Two sample MR report

Telomere_length against wg rh intensity-contrast cuneus

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1553898	0.1466456	0.3013500
Weighted median	23	-0.0853304	0.0618641	0.1677964
Inverse variance weighted	23	-0.0765986	0.0597970	0.2002012
Simple mode	23	-0.0884797	0.1068010	0.4163112
Weighted mode	23	-0.0884797	0.0843198	0.3054153

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.70762	21	0.0013972
Inverse variance weighted	52.13645	22	0.0002993

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0142444	0.0082883	0.1003917

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016975	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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