Two sample MR report

Telomere_length against wg rh intensity-contrast caudalmiddlefrontal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0762337	0.1380004	0.5864955
Weighted median	23	-0.1987451	0.0647818	0.0021556
Inverse variance weighted	23	-0.1692907	0.0533563	0.0015096
Simple mode	23	-0.2111628	0.1138689	0.0771304
Weighted mode	23	-0.1963015	0.0919672	0.0441941

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.47469	21	0.0065077
Inverse variance weighted	41.50904	22	0.0071637

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0057137	0.0077995	0.4719166

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018332	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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