Two sample MR report

Telomere_length against wg rh intensity-contrast caudalanteriorcingulate

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0473422	0.0994064	0.6388143
Weighted median	23	-0.0735848	0.0605346	0.2241435
Inverse variance weighted	23	-0.0946067	0.0388457	0.0148732
Simple mode	23	-0.1408484	0.1129797	0.2256294
Weighted mode	23	-0.1121849	0.0967322	0.2585844

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.74087	21	0.5377240
Inverse variance weighted	20.00768	22	0.5825593

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029021	0.0056183	0.6108743

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000786	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8