Two sample MR report

Telomere_length against wg rh intensity-contrast bankssts

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0969922	0.1595097	0.5496652
Weighted median	23	-0.1334206	0.0629056	0.0339248
Inverse variance weighted	23	-0.0778603	0.0609247	0.2012581
Simple mode	23	-0.1385487	0.1246089	0.2781979
Weighted mode	23	-0.1226978	0.0997068	0.2314732

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	54.07617	21	0.0000963
Inverse variance weighted	54.11989	22	0.0001582

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011747	0.0090152	0.8975668

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017616	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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