Two sample MR report

Telomere_length against wg lh intensity-contrast unknown

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0167429	0.1002250	0.8689262
Weighted median	23	0.0632293	0.0546395	0.2471868
Inverse variance weighted	23	0.0328540	0.0388455	0.3976856
Simple mode	23	0.0761318	0.0834086	0.3712648
Weighted mode	23	0.0389203	0.0615371	0.5335993

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.34732	21	0.4379163
Inverse variance weighted	21.37832	22	0.4974743

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009892	0.0056645	0.8630392

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006695	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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