Two sample MR report

Telomere_length against wg lh intensity-contrast transversetemporal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0541392	0.1305030	0.6824592
Weighted median	23	-0.0858715	0.0633327	0.1751376
Inverse variance weighted	23	-0.0708317	0.0498479	0.1553300
Simple mode	23	0.0641947	0.1252340	0.6133408
Weighted mode	23	-0.0422082	0.0917675	0.6500673

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.19551	21	0.0207848
Inverse variance weighted	36.22879	22	0.0286950

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010249	0.0073758	0.8908074

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011986	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8