Two sample MR report

Telomere_length against wg lh intensity-contrast temporalpole

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0774821	0.1313827	0.5616549
Weighted median	23	-0.1392124	0.0594941	0.0192871
Inverse variance weighted	23	-0.1856352	0.0511066	0.0002809
Simple mode	23	-0.2523795	0.0974167	0.0166847
Weighted mode	23	-0.1400824	0.0594798	0.0278487

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.68379	21	0.0182964
Inverse variance weighted	38.08087	22	0.0179427

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0066406	0.0074254	0.3812974

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018458	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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