Two sample MR report

Telomere_length against wg lh intensity-contrast supramarginal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1068494	0.1580905	0.5064955
Weighted median	23	-0.2427523	0.0667029	0.0002734
Inverse variance weighted	23	-0.2283405	0.0613514	0.0001978
Simple mode	23	-0.2481824	0.1210794	0.0524956
Weighted mode	23	-0.2434755	0.1007767	0.0244400

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	53.12056	21	0.0001322
Inverse variance weighted	54.88370	22	0.0001234

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0074596	0.008935	0.4131853

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0027098	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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