Two sample MR report

Telomere_length against wg lh intensity-contrast superiortemporal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0859589	0.1632111	0.6039397
Weighted median	23	-0.1590035	0.0644730	0.0136555
Inverse variance weighted	23	-0.1910583	0.0630352	0.0024376
Simple mode	23	-0.1840542	0.1029138	0.0874881
Weighted mode	23	-0.1916786	0.1042852	0.0796013

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	56.61706	21	4.09e-05
Inverse variance weighted	57.93652	22	4.49e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0064532	0.0092244	0.4918699

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0024883	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8