Two sample MR report

Telomere_length against wg lh intensity-contrast superiorparietal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0552087	0.1495661	0.7157298
Weighted median	23	-0.2178689	0.0649867	0.0008008
Inverse variance weighted	23	-0.2003164	0.0585939	0.0006292
Simple mode	23	-0.2626502	0.1248285	0.0470247
Weighted mode	23	-0.2317066	0.1053677	0.0386846

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.54401	21	0.0007930
Inverse variance weighted	50.05912	22	0.0005758

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0089096	0.0084531	0.30386

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0023226	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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