Two sample MR report

Telomere_length against wg lh intensity-contrast superiorfrontal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1799059	0.1470114	0.2345985
Weighted median	23	-0.2132995	0.0642091	0.0008939
Inverse variance weighted	23	-0.2099940	0.0561931	0.0001862
Simple mode	23	-0.2637098	0.1093086	0.0246232
Weighted mode	23	-0.2552458	0.1077938	0.0270984

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.93346	21	0.0013041
Inverse variance weighted	46.04159	22	0.0019533

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018474	0.0083088	0.8261936

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0022803	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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