Two sample MR report

Telomere_length against wg lh intensity-contrast rostralmiddlefrontal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0021190	0.1212237	0.9862187
Weighted median	23	-0.1954959	0.0602771	0.0011816
Inverse variance weighted	23	-0.1533355	0.0482635	0.0014878
Simple mode	23	-0.2566317	0.0950735	0.0130993
Weighted mode	23	-0.2192885	0.1023177	0.0434088

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.23176	21	0.0698864
Inverse variance weighted	33.96304	22	0.0495509

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0092848	0.0068513	0.1897613

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015013	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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