Two sample MR report

Telomere_length against wg lh intensity-contrast rostralanteriorcingulate

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0386530	0.1096632	0.7279988
Weighted median	23	-0.1539094	0.0618970	0.0128992
Inverse variance weighted	23	-0.1168968	0.0441722	0.0081356
Simple mode	23	-0.1972153	0.1115108	0.0908299
Weighted mode	23	-0.1854936	0.1081896	0.1004877

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.55788	21	0.2238106
Inverse variance weighted	28.44782	22	0.1613108

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0095508	0.006198	0.1382611

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011364	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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