Two sample MR report

Telomere_length against wg lh intensity-contrast precuneus

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0762038	0.1481075	0.6122636
Weighted median	23	-0.2247721	0.0647952	0.0005225
Inverse variance weighted	23	-0.1897834	0.0574725	0.0009594
Simple mode	23	-0.2769371	0.1180688	0.0284229
Weighted mode	23	-0.2378961	0.0945392	0.0196508

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.61984	21	0.0010562
Inverse variance weighted	48.16070	22	0.0010332

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0069737	0.0083707	0.4141546

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0021825	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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