Two sample MR report

Telomere_length against wg lh intensity-contrast precentral

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2247215	0.1513446	0.1524450
Weighted median	23	-0.1758210	0.0662669	0.0079726
Inverse variance weighted	23	-0.1502495	0.0581742	0.0098016
Simple mode	23	-0.3015368	0.1190945	0.0189930
Weighted mode	23	-0.2188873	0.1086348	0.0562979

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.68176	21	0.0005549
Inverse variance weighted	49.34423	22	0.0007187

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0045726	0.0085537	0.5985583

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019485	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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