Two sample MR report

Telomere_length against wg lh intensity-contrast posteriorcingulate

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0653926	0.1483507	0.6638643
Weighted median	23	-0.0914586	0.0685778	0.1823196
Inverse variance weighted	23	-0.0782012	0.0566515	0.1674662
Simple mode	23	-0.0992197	0.1264545	0.4410398
Weighted mode	23	-0.0709360	0.1028280	0.4975009

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.77181	21	0.0010078
Inverse variance weighted	46.79141	22	0.0015623

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007865	0.0083845	0.9261582

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015406	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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