Two sample MR report

Telomere_length against wg lh intensity-contrast postcentral

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0514760	0.1765155	0.7734360
Weighted median	23	-0.1353721	0.0642125	0.0350146
Inverse variance weighted	23	-0.1434527	0.0679045	0.0346380
Simple mode	23	-0.1353851	0.1215626	0.2774253
Weighted mode	23	-0.1042857	0.1012087	0.3140168

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	66.22146	21	1.4e-06
Inverse variance weighted	67.23196	22	1.8e-06

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0056474	0.0099763	0.5773389

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0024501	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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