Two sample MR report

Telomere_length against wg lh intensity-contrast pericalcarine

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0751734	0.1444526	0.6082273
Weighted median	23	-0.0656706	0.0611305	0.2827021
Inverse variance weighted	23	-0.1089822	0.0576140	0.0585451
Simple mode	23	-0.3260583	0.1297660	0.0198110
Weighted mode	23	0.0066108	0.0673473	0.9226945

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.34562	21	0.0021088
Inverse variance weighted	48.39618	22	0.0009616

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.011307	0.0081641	0.1805986

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017049	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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