Two sample MR report

Telomere_length against wg lh intensity-contrast parstriangularis

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0071949	0.1380002	0.9589126
Weighted median	23	-0.1114282	0.0669834	0.0962087
Inverse variance weighted	23	-0.0986166	0.0535509	0.0655412
Simple mode	23	-0.2454876	0.1156317	0.0452431
Weighted mode	23	-0.2148632	0.1219621	0.0920086

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.47498	21	0.0065071
Inverse variance weighted	41.81231	22	0.0065862

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0064969	0.0077995	0.4142279

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014622	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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