Two sample MR report

Telomere_length against wg lh intensity-contrast parsorbitalis

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1279997	0.1475194	0.3953767
Weighted median	23	-0.1921120	0.0660641	0.0036379
Inverse variance weighted	23	-0.1711220	0.0564562	0.0024370
Simple mode	23	-0.2213656	0.1317238	0.1069999
Weighted mode	23	-0.2124750	0.1177975	0.0849858

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.24933	21	0.0011838
Inverse variance weighted	46.47143	22	0.0017190

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0026477	0.0083376	0.7539496

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019959	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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